Fundamental structure–Activity relationships associated with a new structural class of respiratory syncytial virus inhibitor
Bioorganic & Medicinal Chemistry Letters(2003)
Abstract
Structure–activity relationships surrounding the dialkylamino side chain of a series of benzotriazole-derived inhibitors of respiratory syncytial virus fusion based on the screening lead 1a were examined. The results indicate that the topology of the side chain is important but the terminus element offers considerable latitude to modulate physical properties.
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Key words
physical properties,structure activity relationship
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