膜联蛋白-1在膀胱移行细胞癌发生发展中的表达
Medical Journal of National Defending Forces in Northwest China(2006)
Abstract
目的:探讨AnnexinⅠ在膀胱移行细胞癌、不典型增生及正常膀胱移行上皮组织中的表达,为膀胱移行细胞癌的早期诊断、治疗提供实验和理论依据。方法:应用免疫组化SABC法检测67例膀胱移行细胞癌、22例不典型增生和10例正常膀胱移行上皮组织中AnnexinⅠ的表达。结果:膀胱移行细胞癌、不典型增生和正常膀胱移行上皮组织中AnnexinⅠ的表达率分别为29.85%、31.82%及100%。结论:AnnexinⅠ在正常膀胱移行上皮组织中呈强阳性表达,而在不典型增生及膀胱移行细胞癌中表达明显下降或丢失,提示与移行上皮癌变有关,有望作为膀胱移行细胞癌早期诊断的指标。
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Key words
Annexin Ⅰ,Immunohistochemistry,bladder,Carcinoma
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