Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as γ-secretase inhibitors

A range of substituents was appended from the bridgehead position of sulfonamide substituted bicyclo[4.2.1]nonanes. No improvement in potency for inhibition of γ-secretase was found compared with unsubstituted parent compound, but two compounds displayed improved pharmacokinetic properties in vivo.