Il-12 Induces Sds-Stable Class Ii Alpha Beta Dimers In Murine Dendritic Cells

We assessed the effect of rIL-12 on the expression of class II molecules and on the ratio between SDS-stable and unstable ap dimers in dendritic cells. We found that in vitro exposure of the cells to IL-12 increased their surface expression of mature class II molecules, despite a marked decline in class II biosynthesis. This effect was accompanied by a striking increase in the overall proportion of SDS-stable heterodimers. (C) 2000 Academic Press.