CCR9+ and CD103+ Tolerogenic Dendritic Cell Populations in Food Allergy Patients Undergoing Oral Immunotherapy
Clinical and translational allergy（2011）
Abstract
Rationale CD103+ DCs (dendritic cells) and CCR9+ pDCs (plasmacytoid DCs) have been implicated in promoting tolerance to antigens through regulatory-T cell induction. We have conducted food oral immunotherapy (OIT) clinical studies for the last 3 years at Stanford University. We hypothesized that subjects with food allergies have low CD103+ and CCR9+ expression on their DCs but that these DC populations change over time while on therapy.
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Key words
Food Allergy,Median Fluorescent Intensity,CCL25 Chemokine,Clonal Deletion,Oral Immunotherapy
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