MCP-1 in the cerebrospinal fluid of children with acute lymphoblastic leukemia.
Leukemia research(2006)
摘要
CNS involvement in ALL is associated with significantly higher levels of MCP1 during therapy. This significant rise in MCP-1 levels might be one of the mechanisms involved in the regulation of CNS leukemia. Since chemokines target specific leukocyte subsets, inhibition of a single Chemokine ligand or receptor may have a circumscribed effect, endowing the inhibitor with a limited side effect profile. Chemokines should be considered as possible targets for therapeutic intervention.
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关键词
chemokines,MCP-1,ALL,CNS leukemia
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