Current strategies for prevention of surgical site infections

Surgical site infections (SSIs) are a common complication that follows all types of operative procedures. These infections are usually caused by the exogenous and endogenous microorganisms that enter the operative wound during the course of surgery. The general and procedure-specific risk factors for the development of SSI have been identified and are discussed in this article. Factors that influence the SSI rate and the current strategies for prevention of SSIs are also presented. Emphasis is placed on the efficacious use of antibiotic prophylaxis in surgery. A discussion of the principles of antibiotic prophylaxis, including choice of agents, route of administration, and timing, is offered. It appears that the use of less invasive laparoscopic surgical approaches, as practiced widely today, will be associated with an overall decreased incidence of SSI.