Loss of atheroprotective effect of estradiol in immunodeficient mice.
ENDOCRINOLOGY(2000)
摘要
Estradiol significantly decreases fatty streak formation in the aortic root of chow-fed apolipoprotein E-deficient mice. In contrast, immunodeficient mice with homozygous disruption at the recombinase activating gene 2 loci present fatty streak development that is insensitive to estradiol. Lymphocytes thus appear to be required for development of the atheroprotective effect of estradiol in this mouse model.
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关键词
Adaptive Immunity
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