Identification of a urea bioisostere of a triazole oxytocin antagonist
Bioorganic & Medicinal Chemistry Letters(2010)
Abstract
A series of azetidine ureas, 3, were prepared as potential bioisosteres of previously reported azetidinyltriazole oxytocin antagonists, 4. Several potent analogues were prepared and one, compound, 9, demonstrated significant levels of selectivity over the closely related vasopressin V1A receptor.
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Key words
Oxytocin,Bioisostere
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