奥沙利铂联合卡培他滨治疗进展期胃癌的临床观察

Journal of Basic and Clinical Oncology(2009)

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Abstract
目的观察奥沙利铂(L-OHP)联合卡培他滨治疗晚期胃癌的有效性和安全性。方法晚期胃癌29例采用奥沙利铂130 mg/m2,静脉滴注4 h,d1;卡培他滨1 000 mg/m2,口服,2次/d,d1~14。21 d为1个周期,连用2个周期后评价疗效。结果29例中,完全缓解(CR)1例,占3.4%;部分缓解(PR)13例,占44.8%;稳定(SD)10例,占34.5%;进展(PD)5例,占17.2%。总有效率(CR+PR)为48.3%。毒副反应主要为骨髓抑制、消化道反应和手足综合征等。结论奥沙利铂联合卡培他滨治疗晚期胃癌疗效较好,安全性高。
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Key words
advanced gastric cancer,oxaliplatin,capecitabine,chemotherapy
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