New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors.
Bioorganic & Medicinal Chemistry Letters(2006)
Abstract
Cyclohexylglycine amides of various fluorinated pyrrolidines and azetidines were prepared and tested for activity against dipeptidyl peptidase IV and in vivo in the KK mouse model of type 2 diabetes. The tetrafluoropyrrolidide, cis-3,4-difluoropyrrolidide and the fluorinated azetidides displayed unexpectedly strong activity.
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Key words
Dipeptidyl peptidase IV,DPP-IV,Cyclohexylglycine,Difluoropyrrolidine,Tetrafluoropyrrolidine,Fluoroazetidine,Difluoroazetidine
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