Evaluation of antitumor properties of novel saframycin analogs in vitro and in vivo

Jeffrey R. Spencer,Martin Sendzik,Jason Oeh,Peter Sabbatini,Stacie A. Dalrymple,Catherine Magill,Hyunjin M. Kim,Penglie Zhang,Neil Squires,Katherine G. Moss,Juthamas Sukbuntherng,Doris Graupe,John Eksterowicz,Peter R. Young,Andrew G. Myers,Michael J. Green

Bioorganic & Medicinal Chemistry Letters（2006）

Cited 17|Views44

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Abstract

Novel analogs of (−)-saframycin A are described. Analogs are shown to be potent inhibitors of the in vitro growth of several tumor cells and active antitumor agents in a solid tumor model (HCT-116).

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Key words

Saframycin analog,GI50,DNA binding,Fluorescence,In vivo model

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