Study Of The Enantioselectivity Of Enzymes Involved In Nucleoside Analogue Metabolism: Deoxycytidine Kinase

M Shafiee,V Boudou,Jf Griffon,A Pompon,G Gosselin, S Eriksson,Jl Imbach,G Maury

Nucleosides, Nucleotides & Nucleic Acids（1997）

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摘要

The substrate properties of recombinant human deoxycytidine kinase (dCK) with regard to a series of D- or L-enantiomers of cytidine, 2'-deoxycytidine, and 2',3'-dideoxycytidine analogues were studied using HPLC analysis. Our results suggest that dCK has a remarkably relaxed enantioselectivity with respect to a large number of cytidine derivatives in the beta configuration.

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nucleoside analogue metabolism,deoxycytidine kinase,enantioselectivity,enzymes

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