Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine
NATURE（2006）
Abstract
Targeting cilia Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic condition characterized by the growth of cysts in the kidney tubules and eventual renal failure. As yet there is no effective therapy, but now ( R )-roscovitine, a cyclin-dependent kinase inhibitor with anticancer activity, is showing promise in a mouse model of the disease. The drug may be acting via the cilia that line the kidney tubules.
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Key words
systems biology,cell cycle regulation,neuroscience,metabolomics,physics,materials science,autosomal dominant,climate change,computational biology,geophysics,biology,drug discovery,pharmacology,astrophysics,bioinformatics,cyclin dependent kinase,biochemistry,medicine,proteomics,developmental biology,palaeobiology,functional genomics,genomics,neurobiology,genetics,cell cycle arrest,marine biology,rna,ecology,evolution,dna,evolutionary biology,earth science,cancer,structural biology,nature,nanotechnology,environmental science,immunology,molecular biology,cell cycle,astronomy,signal transduction,biotechnology,transcriptomics,cell signalling,medical research,quantum physics
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