Tryptophan hydroxylase polymorphism and suicidality in unipolar and bipolar affective disorders: a multicenter association study.
Biological Psychiatry（2001）
摘要
%Background:Being the rate-limiting enzyme in the biosynthesis of serotonin, the tryptophan hydroxylase gene (TPH) has been considered a possible candidate gene in bipolar and unipolar affective disorders (BPAD and UPAD). Several studies have investigated the possible role of TPH polymorphisms in affective disorders and suicidal behavior.
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关键词
Bipolar affective disorders,suicide,tryptophan hydroxylase polymorphism,association study,linkage disequilibrium
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