Characterization of extended-spectrum-?-lactamase (CTX-M-15)-producing strains of isolated in France and Senegal
FEMS Microbiology Letters(2004)
摘要
Three clinical isolates of Salmonella enterica recovered between 2000 and 2003 in France and Senegal were found to produce extended-spectrum β-lactamase CTX-M-15. The two isolates from Senegal were recovered from stool of a hospitalized patient with gastroenteritis in 2000 and from an urine specimen of an out-patient with urinary tract infection in 2001. These S. enterica isolates belonged to serotype Kentucky and were clonally related as determined by pulsed-field gel electrophoresis and automated ribotyping. The third isolate of serotype Typhimurium was recovered from a patient hospitalized in France for an acute gastroenteritis acquired in Lebanon. The blaCTX-M-15 gene was located on two different transferable plasmids, one of which also carried blaTEM-1, blaOXA-30, aminoglycoside-, tetracycline-, and sulfamethoxazole–trimethoprim resistance genes. ISEcp1 element was found to be located upstream of blaCTX-M-15 in the same position as reported previously in CTX-M-15-producing Escherichia coli from India and Turkey. This is the first report of blaCTX-M-15 in the genus Salmonella.
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关键词
Salmonella,ESBL,CTX-M-15,Senegal,France
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