W1892 Survival in Enteropathy Associated T-Cell Lymphoma: Type of Lymphoma is Not a Prognostic Factor

through Matrigel compared with SW480 cells transfected with non-targeting control shRNA.CONCLUSIONS.Knockdown of AKT1 in SW480 cells induces EMT formation and promotes cell invasion by downregulating and disrupting E-cadherin expression.Since AKT2 has been implicated in the promotion of CRC cell metastasis, our current study suggests that AKT1 and AKT2 play distinct roles in regulating CRC cell metastasis, thus providing a better understanding of the important and distinct functions of AKT isoforms during CRC progression.