HPLC法测定酚咖片中有关物质对氨基酚的含量
Drug Standards of China(2011)
Abstract
目的:建立酚咖片中有关物质对氨基酚含量的HPLC测定方法。方法:Diamonsil C18(4.6 mm×200 mm,5μm)色谱柱,0.05 mol.L-1醋酸铵溶液为流动相A,甲醇为流动相B,进行梯度洗脱;检测波长为232 nm。结果:对氨基酚在5~15 mg.L-1的浓度范围内线性关系良好(r=0.999 7),最低检测量为4.2×10-4μg(S/N=3),平均加样回收率为100.1%(RSD=0.42%)。结论:本方法快捷、灵敏、准确,可用于酚咖片中对氨基酚的测定。
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Key words
HPLC,Related Substance,p-Aminophenol,Paracetamol and Caffeine Tablets
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