Synthesis And Structure-Activity Relationship Of C-3 Quaternary Ammonium Cephalosporins Exhibiting Anti-Mrsa Activities

Oak K. Kim,Thomas W. Hudyma,John D. Matiskella,Yasutsugu Ueda,Joanne J. Bronson,Muzammil M. Mansuri

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1997）

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摘要

A series of cephalosporins bearing C-3 quaternary ammonium groups were prepared and evaluated for their anti-MRSA activity. They exhibit good to excellent in vitro activity (MICs = 1-8 mu g/mL) against MRSA. (C) 1997 Elsevier Science Ltd.

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structure activity relationship

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