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5(Z)-Benzylidene-1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes as non-steroidal glucocorticoid receptor modulators

Robert J. Ardecky,Andrew R. Hudson,Dean P. Phillips,John S. Tyhonas,Charlotte Deckhut,Thomas L. Lau,Yongkai Li,Esther A. Martinborough,Steven L. Roach,Robert I. Higuchi,Francisco J. Lopez,Keith B. Marschke,Jeffrey N. Miner,Donald S. Karanewsky,Andrés Negro-Vilar,Lin Zhi

Bioorganic & Medicinal Chemistry Letters（2007）

Cited 14|Views20
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Abstract
A series of 5-benzylidene-1,2-dihydro-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes were synthesized and profiled for their ability to act as selective glucocorticoid receptor modulators (SGRMs). The synthesis and structure–activity relationships for this series of compounds are presented.
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Glucocorticoid,Hormone receptor,Cortisol,Inflammation,Prednisolone,Dexamethasone
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