P-473 Phase II trial of temozolomide and innotecan as second-linetreatment for advance non-small cell lung cancer

Background: This study was performed to evaluate the tolerability and efficacy of temozolomide and irinotecan as a second-line regimen in recurrent/metastatic non-small cell lung cancer (NSCLC).Methods: Patients with recurrent/metastatic NSCLC, including those with treated brain metastases, following one prior platinum-ased regimen received temozolomide 75 mg/m(2) daily on days 1 through 15 and irinotecan 100 mg/m(2) on days 8 and 15 every 21 days.Results: The authors treated 46 patients, of whom more that 90% had a performance status of 0 or 1. Four patients (8.7%) attained partial response and 17 (37.0%) had disease stabilization as their best response. The median time to progression was 1.8 months, median overall survival was 9.8 months, and 1-year overall survival was 34%. Grade 1/2 fatigue (63%), anemia (61%), nausea (52%), and diarrhea (44%) were the most common toxicities. Grade 3/4 leukopenia and diarrhea were each observed in 9% of patients. One unexpected death occurred, possibly related to the regimen.Conclusion: Second-line treatment with temozolomide and irinotecan showed tolerable toxicities. The response rates, median survival times, and 1-year survival rates were comparable to other active NSCLC agents.