Adhesion and Proliferation of HUVEC on Poly(D,L-Lactide)-Based Shape Memory Polymers in Vitro

Biodegradable shape memory polymers integrity both excellent biodegradable and shape memory properties,as medical device implanting into human body which can be degraded after finished its function under the action of body fluids and have non-toxicity to human,that avoid secondary surgery on patient suffering and avoid security risks caused by the presence of long-term implantable medical devices.As medical device implants should have good cytocompatibility.Poly D,L-lactic acid based shape-memory polymer(PDLLA-PUU SMPs)with human umbilical vein endothelial cells were cultured in vitro.Adopting the laying of the membrane method and extracting method,the ability of HUVEC proliferation was estimated by MTT assay and cell morphology was observed using HE staining method.Compared with PDLLA controls,all results showed that PDLLA-PUU SMPs had the better cytocompatibility.