Short Communication: Lack ofin VitroAnti-gp160 Antibody Production Is a Correlate of Nonprogression among HIV Type 1-Infected Individuals
AIDS RESEARCH AND HUMAN RETROVIRUSES(2009)
Abstract
The aim of our study was to investigate the possible correlation of in vitro antibody production (IVAP) directed to the gp160 protein of HIV-1 with CD4(+) slopes, plasma viremia, and disease progression in long-term nonprogressors (LTNPs). Nineteen subjects with a long-term nonprogressive HIV-1 infection were studied and followed for 2 years, During the follow-up, in vitro anti-gp160 producers showed negative CD4(+) slopes in the majority of cases (9 of 12), whereas 5 of 7 nonproducers showed positive CD4(+) slopes. Plasma viremia values, which were not significantly different in the two groups at baseline, became significantly higher in anti-gp160 producers when compared with nonproducers during the follow-up (p = 0.012). Finally, a trend toward progression was observed in the group of producers but not in nonproducers, These findings suggest that the in vitro production of anti-gp160 antibodies by peripheral B cells is not a correlate of protection, and may represent an early predictor of progression in LTNPs.
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