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Synthesis of 2?,3?-dideoxy-2?-hydroxymethyl nucleosides

C. R. Noe,H.-P. Buchstaller, G. Haberhauer, A. Holzner

MONATSHEFTE FUR CHEMIE（1997）

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Abstract
The synthesis of protected 2',3'-dideoxy-2'-hydroxymethyl nucleosides is presented. The nucleo sides, obtained in a multi-step procedure starting from isopropylideneglycerol, may be used as building blocks for the synthesis of 2',5'-ether linked oligonucleotides.
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Key words
nucleoside analogon,nucleoside synthesis,isopropylideneglycerol,chiral pool
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