[Effect of electroacupuncture intervention on blood-lipid, high-sensitivity C-reactive protein and adiponectin levels in hyperlipidemia rats].

OBJECTIVE:To observe the effect of electroacupuncture (EA) stimulation of "Zusanli" (ST 36) and "Zhongwan" (CV 12) on blood-lipid, high-sensitivity C-reactive protein (HS-CRP) and adiponectin (ADPN) levels in hyperlipidemia rats, so as to study its mechanisms underlying improvement of hyperlipidemia. METHODS:Thirty-two male Wistar rats were randomly divided into control group, model group, manual acupuncture group and EA group (n = 8 in each group). Hyperlipedemia model was established by feeding the rats with high fat diet for 40 days. Manual acupuncture and EA stimulation were separately applied to unilateral "Zusanli" (ST 36) and "Zhongwan" (CV 12),once daily for 4 weeks. Serum triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) levels were determined by chromatometry, and serum HS-CRP and ADPN contents detected by immunity turbidimetric method and euzymelinked immunosorbent assay, respectively. RESULTS:Compared with the control group, serum TC, TG, LDL-C and HS-CRP levels were significantly upregulated in the model group (P < 0.05, P < 0.01), while serum HDL-C and ADPN levels remarkably reduced after modeling (P < 0.05, P < 0.01). In comparison with the model group, serum TC, TG, LDL-C and HS-CRP contents were considerably decreased in both manual acupuncture and EA groups (P < 0.05, P < 0.01), and serum HDL-C and ADPN contents were evidently upregulated in the manual acupuncture and EA groups (P < 0.05, P < 0.01). The effect of EA in decreasing serum TC, TG, LDL-C and HS-CRP, and increasing serum ADPN was superior to that of manual acupuncture (P < 0.05). CONCLUSION:EA intervention has a remarkably positive effect on hyperlipidemia by reducing serum TC, TG, LDL-C and HS-CRP contents and upregulating serum HDL-C and ADPN levels in hyperlipidemic rats.