Anilinopyrimidines As Corticotropin Releasing Hormone (Crh) Antagonists.

Ag Arvanitis,Pe Aldrich,Cr Arnold, R Bakthavatchalam,Jp Beck, Pj Bouchard, Rs Cheeseman,Dr Chidester,Rj Chorvat,Te Christos,Aj Coccuza,Sg Culp, M Curry, Lw Fitzerald,Pj Gilligan,Pr Hartig,L He,Fw Hobbs,Cn Hodge,Pj Krenitsky,De Mccall,Jt Rescinito,El Scholfield,Sw Tam,Gl Trainor,Zr Wasserman,Rg Wilde,Ja Yarem, R Zaczek

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1996）

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摘要

A series of 4-aryl-2-(N-ethylanilino)pyrimidines has been synthesized as corticotropin-releasing hormone (CRH) inhibitors. The effect of substitution on each aromatic ring on receptor binding was investigated. (C) 1999 DuPont Pharmaceuticals. Published by Elsevier Science Ltd. All rights reserved.

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Hepatoprotective

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