Study of the treatment of hypertension in mice with Cirsium japonicum DC decoction

In this study,the effects of Cirsium japonicum DC decoction(CJDC) on anti-hypertension,the structure and weight of heart,kidney and other organs in mice model of hypertension were explored,and blood coagulation was detected.The results showed that a moderate dose of CJDC could significantly reduce blood pressure to the normal level in hypertensive mice,and no significant effects were found on the ratios of viscera to body of heart,liver,kidney,spleen and thymus.There were significant increases in the density of kidney and heart tissue and decreases in the renal capsule in hypertensive mice,which returned to the normal level in treatment mice.CJDC could also significantly shorten the time of blood coagulation in the treated mice.Conclusion: A moderate dose of CJDC could significantly lower the blood pressure as well as protects the heart and kidney better in the treated mice.It also increased hemostatically with positive correlation to the dose,so the dosage should be appropriate.