Par-4 is an essential downstream target of Dlk in Dlk/Par-4-mediated apoptosis

ABSTRACT Prostate apoptosis response-4 (Par-4) was initially identified as a gene product upregulated in prostate cancer cells undergoing apoptosis. In rat fibroblasts, co-expression of Par-4 and its interaction partner DAP-like kinase (Dlk/ZIP kinase) induces relocation of the ,kinase from the nucleus to the actin filament system, followed by extensive myosin light chain (MLC)