[270] PROSPECTIVE INFLUENCE OF HFE GENE MUTATIONS AND LIVER IRON OVERLOAD ON THE RISK OF HEPATOCELLULAR CARCINOMA OCCURRENCE IN PATIENTS WITH ALCOHOLIC OR HCV-RELATED CIRRHOSIS

Aim of this study is to compare RFA to RES in a restricted cohort of patients with a first diagnosis of single HCC ranging from 3 to 5 cm and with not end stage liver disease.Patients and Methods: 10 I patients never treated before were enrolled.Those patients whose HCC position required too parenchimal lost at RES (central or close to main vascular structures) were treated with RFA (60), others underwent RES (41).The two groups were similar for HCC size (mean RES:RFA = 40:36 mm) and liver disease status.The outcome was considered in terms of overall survival (O.S.) and disease free survival (DFS) calculated with Kaplan-Meier method.Differences among groups were validated by Log-rank test.Results: O.S.% in RESIRFA at I , 2, 3, 4, 5 years: 91/96, 72177, 55153, 45135,42130.DFS% in RESIRFA at I , 2, 3, 4, 5 years: 76167,44142, 3511 8, 18113, 1510.Even if RES group seems to present a better long term O.S. and DFS this difference does not reach a statistical significance.Patients with worse Child-Pugh score (B vs A) and patients that have a recurrence within the first 12 month after treatment show a worse long term survival.Conclusion: It seems that Resection and RFA have the same efficacy in treating HCC ranging from 3 to 5 cm.Survival may be mostly related to nature of HCC itself and to liver disease on the background.A larger sample size is required to confirm this observation.