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Frequency of resistant virus and options for a second-line treatment for HIV-1 infected children under HAART in Mozambique

Marie-Laure Chaix,Ilesh Jani,Eugenia Macassa,Dulce Bila,Adolfo Vubil,Soren Andersson,Christine Rouzioux,Paula Vaz, Stéphane Blanche

Retrovirology（2009）

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Abstract
Methods Between December 2003 and December 2006, 515 children (median age: 36.8 months) were included, 97% received a combination of d4T plus 3TC and nevirapine. HIV-1 RNA was transversally performed once using the Roche Amplicor v1.5 test. HIV-1 genotypic resistance tests were performed on available plasma samples when HIV-1 RNA was > 3 log10 copies/ml. Drug resistance was interpreted according to the 2007 French ANRS resistance algorithm.
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Key words
Lamivudine,Tenofovir,Nevirapine,Resistant Virus,Abacavir
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