Syntheses of Pantolactone and Pantothenic Acid Derivatives as Potential Lipid Regulating Agents

Daniela Oniciu,Roel Bell,Bruce McCosar,Charles Bisgaier,Jean‐Louis Dasseux,Dennis Verdijk,Mike Relou,Dennis Smith,Henk Regeling,Frank Leemhuis,Eelco Ebbers,Ralf Mueller,Lianhao Zhang,Emil Pop,Clay Cramer,Brian Goetz,Andrew McKee,Michael Pape,Brian Krause

SYNTHETIC COMMUNICATIONS（2006）

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摘要

A series of pantolactone and pantothenic acid derivatives (1-10) were synthesized to be tested for their potential as lipid regulating agents that act as Coenzyme-A mimics. The syntheses were performed with moderate to high yields.

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关键词

pantolactone,pantothenic acid,coenzyme-A,dyslipidemia,metabolic disorder

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