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Testing Developmental Neurotoxicity: Saving Animals By In Vivo Imaging With Pet And Mri

D DEGROOT,N JETTEN,B VOET,A WOLTERBEEK,A VELTIEN,A HEERSCHAP,R DIERKX, A VANWAARDE,A WILLEMSEN, E DEVRIES

TOXICOLOGY LETTERS（2008）

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Abstract
A novel amphiphilic contrast agent, a GdPCTA-[12] derivative containing a dodecyl chain as lipophilic moiety, has been prepared. A convergent synthetic route from commercially available diethylene triamine and 3-hydroxypyridine is described. The target amphiphilic gadolinium complex was obtained in nine steps in 22% overall yield. Physicochemical properties and relaxivity measurements of this new contrast agent are described.
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in vivo imaging
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