MK-801对吗啡依赖大鼠戒断症状及中枢cAMP含量的影响
Chinese Pharmacological Bulletin(2006)
Abstract
目的观察MK-801对吗啡依赖大鼠戒断症状及脊髓和脑干cAMP含量的影响。方法选择♂性SD大鼠32只,随机分为盐水对照组、吗啡依赖组、吗啡戒断组和MK-801组,每组8只。各组在纳洛酮激发戒断后立即观察戒断症状30min,纳洛酮激发戒断后1h,处死大鼠,分离脊髓和脑干,用放射免疫法检测cAMP的含量。结果MK-801组戒断症状总分为26.06±1.98,低于吗啡戒断组61.15±3.28(P<0.01)。MK-801组脊髓cAMP含量为0.8±0.26μmol.g-1,低于吗啡戒断组(P<0.05),而与吗啡依赖组相近(P>0.05);MK-801组脑干cAMP含量为1.62±0.38μmol.g-1,低于吗啡戒断组(P<0.05),而与吗啡依赖组相近(P>0.05)。结论MK-801减轻吗啡戒断症状的机制可能与其降低大鼠中枢cAMP的水平有关。
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Key words
cAMP,MK-801,Morphine,Withdrawal
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