573: Regulation of maternal feeding during lactation period may control adulthood hypertension

Exposure to undernutrition during fetal life has been proposed as an underlying cause of adult hypertension, but the effect of either high fat nourishment or undernutrition during lactation period on blood pressure is unclear. Our objective was to investigate the most effective maternal nourishment and feeding period for offspring induced adulthood hypertension in using high-fat diet (HFD). We use 5 types pregnant Wistar rats as fed with normal nutrition (Group A), nutritionally restricted by feeding with 30% of the normal gestation-matched dietary intake from day 17 of gestation to delivery (Group B), 30% restricted after delivery to the end of lactation period (Group C), with a high fat diet (HFD) during gestation to lactation period (Group D) and with HFD nutritionally 30% restricted from the day of delivery to the end of lactation period (Group E). The offspring was measured Body Weight (BW) and measured blood pressure at 12, 24 and 60 weeks by using indirect tail-cuff method. Statically analysis was performed using one-way ANNOVA. BW was significantly reduced in B offspring compared to another (A, C, D, E) male offspring at day 1 (p<0.01). At day 28 after delivery, BW was significantly reduced in C, E offspring compared to A, D in male offspring (p<0.01). At 12 weeks old, BW of all type offspring was no difference. Systolic and Diastolic blood pressures were significantly elevated at 12 and 60 weeks in offspring of D> E > B > C >A. (p<0.01, vs. A). At 24 weeks, hypertensive offspring as B>D>E>C>A. (p<0.01, vs. A) Maternal high fat environment make a hypertensive offspring, but regulation of fat feeding during lactation period may reduce adulthood hypertension. In case with normal food, restrictive feeding during late gestation is more effective than lactation period for inducing hypertensive male offspring.