Expression Changes of ERK1/2, STAT3 and SHP-2 in Bone Marrow Cells from γ-ray Induced Leukemia Mice

Zhichao FU,Dingde HUANG,Jianming CAI,Qi CHEN,Ling HAN,Bailong LI,Fengmei WANG,Jianguo GAO

Journal of Radiation Research（2006）

Cited 12|Views17

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Abstract

The aim is to clarify expression changes of ERK1/2, STAT3 and SHP-2 in bone marrow cells from γ-ray induced leukemia mice. A mouse model of γ-ray induced leukemia was produced, and by means of quantitative real-time PCR, immunoprecipitation, Western blotting and electrophoretic mobility shift assays (EMSA), the expression of mRNA and protein, phosphorylation level, and protein activity of ERK1/2, ...

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Key words

Radiation carcinogenesis,SHP-2,MAPK,STAT,Leukaemia

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