Neutrophil Migration Activity (NMA) — A new migration test for the monitoring of wound healing in traumatology?
European Journal of Orthopaedic Surgery & Traumatology(1995)
摘要
Summary A new PMN migration test was introduced in traumatology to measure the acute, inflammatory response after surgery in a patient
with uncomplicated wound healing and in a case of acute, early postoperative infection. Polymorphonuclear neutrophil granulocyte
(PMN) — behaviour was studied by quantifying the neutrophil migration activity (NMA), which combines PMN-stimulation and PMN-distribution
in a migration filter device simulating “in vivo”-conditions. While in uncomplicated wound healing the NMA was within the
normal range, in an acute, early infection migratory stimulation reached a maximum on the 5th postsurgical day followed by
a decrease during the following days. This decrease is probably an expression of an increased PMN-turnover and excessive phagocytosis.
PMN-behaviour changing from migration to phagocytosis is regarded as an indicator of wound healing complications before clinical
symptoms occur.
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关键词
Neutrophil migration test, Acute inflammatory response, Wound healing monitoring, Activité migratoire neutrophile, Monitoring de cicatrisation, Réaction inflammatoire immédiate, 1624.0
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