Clinical observation of intravenous buprenorphine-midazolam in operation of uterine cervix cancer

Objective:To investigate the sedative,preventive effects against entrails pain and the influence of circulation and respiratory of intravenous administration of buprenorphine-midazolam in patients under epidural anesthesia in the operation of uterine cervix cancer.Methods:Sixty patients undergone uterine cervix cancer surgery were divided randomly into two groups (n=30).Group B received 0.15mg buprenorphine + 4mg midazolam;Group F received 0.1mg fantanyl + 4mg midazolam.All the drugs or 3/4 of the dose were intravenously injected 5 minutes before skin incision.Cortisol and blood sugar level at defined time were measured and compared.The blood pressure,heart rate,SpO2 and respiratory frequency were monitored.The degree of sedation and the entrails pain were recorded during the operation.Results:Ten min after administer,the levels of cortisol in blood was higher than those before the operation (P0.05).Group F was significantly higher than group B after 30min administration (P0.05).Besides,blood sugar in both groups was higher than those before the operation (P0.05).Group B was significantly better in sedative action,decreasing ent rails pain than group F (P0.05).Both two groups had no significant influence on circulation and respiratory (P0.05).Conclusion:Buprenorphine-midazolam could relieve the increase of cortisol and blood sugar content resulting from stress response in the operation of uterine cervix cancer.Buprenorphine-midazolam also can increase sedative action,decrease entrails pain,and does not significantly influence circulation and respiratory under epidural anesthesia.It can be safely used in epidural anesthesia in the operation of uterine cervix cancer.