Neo-tanshinlactone inspired synthesis, in vitro evaluation of novel substituted benzocoumarin derivatives as potent anti-breast cancer agents

Koneni V. Sashidhara,Jammikuntla N. Rosaiah,Manoj Kumar,Rishi Kumar Gara,Lakshma Vadithe Nayak,Kamini Srivastava,Hemant Kumar Bid,Rituraj Konwar

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

A small library of novel benzocoumarin derivatives based on naturally occurring neo-tanshinlactone scaffold was constructed and some of them showed better activity then the reference compound tamoxifen.

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关键词

Synthesis,Neo-tanshinlactone,Benzocoumarins,Anti-breast cancer agents,Apoptosis

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