Spindle Cell Carcinoma of the Tongue in a Long-Term Survivor of Childhood Acute Lymphoblastic Leukemia

A 25-year-old male previously treated (age 9 years) for acute lymphoblastic leukemia developed a spindle cell carcinoma of the tongue. Possible causes for the development of his second malignancy are discussed. A combination of scatter from cranial irradiation, poor oral hygiene, alcohol consumption, and cigarette smoking is likely to be contributory. Genetic predisposition can never be fully excluded.