The Relationship Between Blood Glucose Excursions And Microalbuminuria In Early Diabetic Nephropathy

Objective Aims To examine the relationship between blood glucose excursions and microalbuminuria in early diabetic nephropathy.Methods 80 Type 2 diabetic patients(40 UAER≤20 μg/min,40 UAER 20-199 μg/min) wore continuous glucose monitoring systems for 3 days.The average glucose,mean amplitude of glycaemic excuisions(MAGE) and the standard deviation of blood glucose(SDBG) were calculated.Results There was no difference in the mean glucose between both groups,the diabetic nephropathy group had a greater MAGE(6.2±0.6 mmol/l vs 3.4±0.4 mmol/l)and a greater SDBG(3.14±0.94 mmol/l vs 2.21±0.64 mmol/l).Conclusion Patients with early diabetic nephropathy have greater glucose excursion compared with patients who have no urinary microalbuminuria.