Effect of Toluene Intoxication on Spatial Behavior and Learning of Rats within Early Stages of Postnatal Development

Toluene inhalation-induced intoxication (500 ррm) of albino mongrel rats within early stages of postnatal development (to postnatal day Р30) significantly suppressed realization of auriculonasocephalic reflex within the time interval preceding the period of beginning of visual perception, i.e., eye opening in young animals (Р7 to Р13). Later on (Р15 and Р21), we observed a drop in the motivation level and disorders of learning processes in the course of testing in a water corridor. Results of testing of a passive avoidance reaction after toluene intoxication during Р30 indicated that the ability of intoxicated animals to consolidate memory traces noticeably decreased.