A Potent Hiv Protease Inhibitor Identified In An Epirneric Mixture By High-Resolution Protein Crystallography

Silvano Geremia,Nicola Demitri,Jochen Wuerges,Fabio Benedetti,Federico Berti,Gianluca Tell,Lucio Randaccio

CHEMMEDCHEM（2006）

引用 7|浏览5

暂无评分

摘要

Discovery by co-crystallization: High-resolution electron-density maps of HIV-1 aspartyl protease complexed with a potent Phe-Pro isostere-based inhibitor (shown) allowed the determination of the stereochemistry of the inhibitor and an initial assessment of the inhibition properties of this compound without its purification from the epimeric mixture.

查看译文

关键词

x ray diffraction,peptidomimetics,protein structures,high resolution,protein crystallography

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要