A Web Based System for Computation and Management of Massive Number of 2-D Gel Electrophoretograms of Genomic DNA

IntroductionDNA methylation occurring within the context of CpG site in the promoter element generally correlateswith transcriptional silencing, delayed replication and condensed chromatin [ ]. Recently, it wasreported that CpG-islandsofseveral tumor-suppressor gene promoters were hypermethylated in tumorand there were tumor-type-specific hypermethylation patterns [3]. It is also strongly suggested thatDNA methylation correlates to mammalian genome imprinting.Restriction landmark...