Synthesis, gene-silencing activity and nuclease resistance of 3'-3'-linked double short hairpin RNA.

Hirofumi Masuda,Naoki Watanabe,Haruna Naruoka,Seigo Nagata,Kazuchika Takagaki,Takeshi Wada,Junichi Yano

Bioorganic & Medicinal Chemistry（2010）

Cited 8|Views3

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Abstract

Short hairpin RNAs linked at their 3′ ends by glycerol show structure-dependent gene-silencing activity as well as higher exonuclease resistance and lower induction of interferon-α than siRNA or canonical shRNA.

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Key words

3′–3′-Linked double short hairpin RNA,Gene-silencing activity,Nuclease resistance,Innate immune response

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