Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ

Lloyd G. Czaplewski,Ian Collins,E. Andrew Boyd,David Brown,Stephen P. East,Mihaly Gardiner,Rowena Fletcher,David J. Haydon,Vincent Henstock,Peter Ingram,Clare Jones,Caterina Noula,Leanne Kennison,Chris Rockley,Valerie Rose,Helena B. Thomaides-Brears,Rebecca Ure,Mark Whittaker,Neil R. Stokes

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要

3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure–activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.

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关键词

Antibacterial,Alkoxybenzamide,FtsZ,3-Methoxybenzamide,Antibacterial efficiency

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