The Effect Of Delta-7-Cholestenol Feeding On The Cholesterol And Lipoproteins Of Rabbit Serum

1.1.When Δ7-cholestenol is fed to rabbits there is produced a rise in the various classes of low-density serum lipoproteins. The lipoprotein “pattern” is qualitatively the same as that observed after feeding cholesterol.2.2. Δ7-Cholestenol produces a striking rise in serum cholesterol, and about the same levels are reached as are observed on feeding cholesterol itself. The sterols of the serum after this feeding show a maximum of about 12% of Δ7-cholestenol.3.3. Δ7-Cholestenol and cholesterol produce an additive effect on the levels of serum lipoproteins when fed simultaneously.4.4. Five per cent of the serum sterols is Δ7-cholestenol at the end of 1 week of feeding both this sterol and cholesterol. At the end of 2 weeks the Δ7-cholestenol falls almost to zero in spite of continued feeding of both sterols.