Local and systemic expression of basic fibroblast growth factor in a patient with familial glomangioma.
BRITISH JOURNAL OF DERMATOLOGY(2002)
摘要
Glomangiomas are rare cutaneous tumours composed of glomus cells, which are modified smooth muscle cells. The aetiology of this condition is thought to involve a mutation in a novel gene acting to regulate angiogenesis. We report a patient from a large family with three generations affected by familial multiple glomangiomas. We hypothesized that the growth factors basic fibroblast growth factor and vascular endothelial growth factor, which stimulate/regulate angiogenesis could be involved in the pathogenesis of these lesions. Therefore, using enzyme-linked immunosorbent assays and immunohistochemistry, respectively, we measured systemic and tissue levels of these growth factors in a patient with familial glomangiomas. In addition, we investigated endothelial mitogenicity of the patient's serum as a functional assay of systemic growth factor activity.
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关键词
endothelial mitogenicity,fibroblast growth factor (FGF),glomangiomas,vascular endothelial growth factor (VEGF)
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