Microsatellite Instability May Be Uncommon Among Hispanics with Colorectal Cancer

adenomas.No association was observed between SLC5A8 methylation and the patients' age, gender or type of adenoma.The proteomic analysis revealed that H4 and H2A/z were more than two folds upregulated in adenoma samples.High level methylation of SLC5A8 and up-regulation of HDAC2 is consistent with the lack of functional SLC5A8 protein to inhibit cell proliferation.In addition, alteration of H4 (Triacetyl monomethyl and triacetyl dimethyl) and HDAC2 expression seem to impact directly the expression profiles of many histones that play a direct role in chromatin condensation and gene expression that might be associated with proliferation as confirmed by an increase in Ki67 expression, a proliferation marker, from10.2% in normal to 26.7% in carcinoma tissue.Together, SLC5A8 methylation, H4, HDAC2 expression may be associated with colon adenoma development.