Overcoming Opioid Blockade From Depot Naltrexone (Prodetoxon((R)))

Aim To describe a situation in which an opioid-dependent patient overcame naltrexone blockade. Design, case report, setting Addiction treatment center in St Petersburg, Russia. Participant Patient with naltrexone implant. Intervention Detoxification. Measurements Clinical observations. Conclusions It is possible, but very difficult, to overcome naltrexone blockade by using large doses of heroin.