直链淀粉手性固定相高效液相色谱法分离泮托拉唑钠对映体及应用
Chinese Journal of Analysis Laboratory（2009）
Abstract
用手性固定相法拆分泮托拉唑钠对映体,并建立了检测泮托拉唑钠对映体光学纯度的HPLC方法。色谱柱为Chiralpak AD-H柱(250×4.6 mm,5μm),流动相为V(正己烷)∶V(异丙醇)=40∶60,流速为0.5 mL/min,检测波长为288 nm。该法可用于左旋泮托拉唑钠原料药和制剂的质量控制。
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Key words
HPLC,Pantoprazole sodium,Chiral stationary phase,Chiralpak AD-H
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